We finally tracked this down: Pop idol turned shaggy-beclaptoned bluesman John Mayer may have deserved the Grammy for the most stoned-looking person to take the stage, but he was quick on his feet when Ryan Seacrest asked him about his relationship with the half-his-size Jessica Simpson.
You can fill in the translation.
The bilingual Mayer allegedly says: "She is very beautiful... and you're the last to know." It's got nothing on his duet with Dave Chappelle, but it'll have to do for now...